Buari is the daughter of Sidiku Buari, a Ghanaian musician. She studied performing arts at the University of Ghana and graduated with a BFA degree. She was born in Takoradi, Ghana to a musician and a producer called Alhaji Sidiku Buari and mother who is a beautician called Hajia Buari. Throughout her school life she was actively involved in school drama and dance clubsBuari premiered on Ghanaian national television with the TV series Games People Play in late 2005. Her first major film was Mummy's Daughter, after which she starred in Beyonce: The President's Daughter. Her role as "Beyonce" was her major breakthrough. Her movie career began with her playing a role in the TV series Games People Play in 2005, which she got nominated for best actress. She has starred in more than 20 movies. In 2013, she came out with her own movie called The Diary of Imogen Brown.

Buari moved from Ghanaian films to Nollywood films around the year 2008. Her breakthrough role in Nollywood was in the film Beyonce & Rihanna as Beyonce alongside Nollywood actress Omotola Jalade Ekeinde who played Rihanna. The film became very popular to both Ghanaian and Nigerian audience. Her other notable Nollywood films include Rough Rider, Beauty and the Beast, Holding Hope and Single and Married.

She is also known for co-starring in films with Nollywood actor Jim Iyke, which has also received attention. Films include the Beyonce & Rihanna film series, Hot Romance and Behind a Smile.

In 2013, She won the Pan African Actress award at the annual Nigerian Entertainment Awards (NEA Awards) in New York City.

Buari is an ambassador at Tablet India Limited (TIL), a leading pharmaceutical manufacturer with high quality products in 2013.In January 2014, she dated Nollywood actor Jim Iyke.[15] On 21 March 2014, Jim Iyke proposed to Buari. She is a mother of twin girls but Jim Iyke is not the father.