Isime hails from Esan in Edo State. She grew up in Lagos where she had her primary and junior secondary education. Afterwards, she left for Benin, where I had my senior secondary education. She took a six-month basic course at the University of Port Harcourt and a Diploma in Social Work at the University of Lagos.

In 2009, Isime won the Miss Valentine International beauty pageant, and finished second in the Miss Telecoms Nigeria beauty contest. Nancy is an accomplished model that has graced several magazine covers like: Wedding Planner, Paparazzi Fashion Magazine, LIFE(Ghana), House of Marie, Ade Bakere, Adebayo Jones, Zizi Cardow, Shakara Couture, Konga Online and others.

Isime began a career as an actress in the TV series Echoes in 2011. She appeared in several films in 2014. Isime is also a television presenter, known for presenting gossip show The Squeeze, technology show What’s Hot and backstage segments of MTN Project Fame season 7. In 2016 she replaced Toke Makinwa as the presenter of the popular show Trending on HipTV.

For music videos, she has appeared in 2Face’s Ihaneme, Solid Star’s Omotena, Hennessy Artistry Featuring MI and Naeto C, Winner of Glo Naija Sing Casey Ed’s Not the Girl, e.t.c.

Face of Bella Hair Collection (Rana Prestige Industry) and Former Face of Total Wrap Online Store.
In 2016, she was voted City People Entertainment Award VJ of the Year.