Stephanie Okereke was born in Ngor Okpala, Imo State. She is the sixth child of Mary and Chima Okereke's eight children. She completed her primary & secondary education in Delta State.She studied at the University of Calabar, in Cross River State, where she graduated with a degree in English and Literary Studies.

Already during her teenage years in 1997 she starred in two Nollywood movies, Compromise 2 and Waterloo. During the 2002 Most beautiful girl in Nigeria beauty pageant Okereke reached 2nd place. A year later in 2003, Okereke won two awards, out of the eight nominations she received, at the 2003 Reel Awards for 'Best Actress - English' and 'Best Actress of the year 2003'. After graduating from the New York Film Academy in 2007, Okereke released the movie Through the Glass in which she served as director, scriptwriter, producer and actress. The film received an Africa Movie Academy Award nomination for Best Screenplay in 2009. In 2014, she release another movie, Dry and again served as a director, scriptwriter, producer, and actress which won many awards including 12th Africa Movie Academy Awards and 2016 Africa Magic Viewers Choice Awards best movie overall movie with the prize of a brand new car . Okereke has starred in over 90 movies.